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What should I use to synthesize procedural audio in real time according to user input?

I need to make some sort of program that generates and plays procedural audio in real time based on user input. The interface can be completely bare-bones – The software just needs to be potentially capable of listening to input from an Arduino. I am a complete beginner to low-level programming, so I was hoping someone could help me figure out where to start. Should I use C# with Visual Studio and some audio library, a game engine (none of which seem to be particularly optimized for real-time audio synthesis), or something else? I feel like I would also run into an optimization wall using Python and PyAudio, but let me know if I’m wrong.