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Sending a mass email mail-out to 35,000 email addresses

I have a list of 35,000 email addresses I need to email. My programmer friend mentioned OpenCL installed on RK1, as a process of how to do that. Basically, I would just like to know how to set it up, like what is a script, and what kind of back-end process is needed, since getting an email into the Primary Inbox instead of the Spam box is pretty hard to do nowadays.